Factual error: When Vittoria shows Kohler and Langdon the underground lab, she searches for the dial tone on her cellphone (and fails as they are underground), thrice. Cellphones don't have dial tones.

Factual error: The book erroneously claims that St. Peter's Square is not located in Vatican City, but in Rome proper. Although located outside the perimeter wall of the original Vatican complex, it does lie within the boundaries of present-day Vatican City, established in 1929.

Factual error: At the end of the book (spoiler alert) the cardinal, Mortati, states that the pope did not sin when he had a child with Maria via artificial insemination. For the Catholic church, this is false. The church condemns unnatural sexual acts between two persons, one of the most unnatural being artificial insemination. The idea that the pope's "devil's advocate" would allow this behavior is absurd.

Factual error: In one of his lectures Robert Langdon tells his students that the Christians got their tradition of communion, eating their god, from the Aztecs. The Aztec civilization dates to the 13th century while the tradition of communion is as old as Christianity itself. And even disregarding when the Aztecs lived, the Europeans had no contact with America until the late 15th century and could thus not have gotten any traditions that way.

Factual error: Maximilian Kohler makes a point of Copernicus (along with many other scientists) being murdered by the church for revealing scientific proof that contradicted the church. However Copernicus actually died from a stroke.

Factual error: At the fourth altar of science a man is drowned in the Fontana dei Quattro Fiumi, and Langdon swims around in the water. That would be hard to do, considering the depth of the fountain is little more than one foot.

Factual error: The book claims that St. Peter's is adorned by 140 statues. St. Peter's has only 13 statues - Christ and his apostles.

Factual error: Robert Langdon insists that Harvard astronomer Edwin Hubble proposed the theory of the Big Bang. Hubble never was associated with Harvard.

Plot hole: The main reason the antimatter bomb was not found, according to the book, is because it is small enough to be hidden anywhere. However, there was a wireless camera watching the bomb all the time. The wireless camera, just like any wireless device, is basically a radio transmitter and receiver, so all they would need is a device displaying the signal strength coming from the camera (having no such device, the CERN could probably borrow some). Where the signal is the strongest, there is the bomb. It is improbable that there wasn't a single person understanding how wireless devices work.

Factual error: The book states that Sant' Agnese in Agone is located in the east of Piazza Navona. It is actually in the west.

Continuity: In chapter 21 (page 97 in my British Corgi edition) Vittoria says she and her father collected five thousand nanograms of antimatter. However, in chapter 22 (page 101) when Vittoria is about to remove the trap, Kohler says "Five hundred nanograms!", not five thousand. As there is such a huge amount of power in a tiny amount of antimatter, there would be an enormous difference between 500 and 5000 nanograms and Kohler, as an expert scientist, would know this and not make that mistake.

Factual error: Cardinal Mortati states that he was Devil's Advocate at the late Pope's confirmation. The Devil's Advocate argued against the canonization of saints, not the confirmation of Popes, until the position was abolished.

Other: In the beginning of the book, when Langdon arrives at Genève, he says that it was 64 minutes since he began to fly. A little later he says that he has flown 17,000 kilometres per hour. But then he would have flown 17,000 km, and there is absolutely not 17,000 km from Boston to Genève.

Factual error: The book places St. Peter's basilica in the Vatican Museums. St. Peter's is located outside the Museums.

Factual error: Despite Dan Brown's claim that the facts and places of the book are real and haven't been altered, the geography of Rome is very inaccurate. The map provided in the book is not consistent with a real map of Rome. Interestingly enough, if you try to map out the way to Illuminati's headquarters as it is depicted in the book, neither a real map of Rome nor the fake one in the book will lead you to the same place as it lead Langdon.

Continuity: When Langdon, Vittoria, Ollivetti and a Swiss guard driver are in the car, the driver says "My wife and I -" before being cut off by Ollivetti, but in an earlier chapter the book states that Swiss Guard must be unmarried.

Factual error: According to the book the statue The Ecstasy of St. Teresa was rejected by the pope for being too sexual in nature. Actually the statue was commissioned by the pope for the exact church where you find it in the book.

Plot hole: The Swiss guard are having great trouble finding the antimatter because it's in a container with no metal components etc., but right next to the antimatter is the security camera. The security camera not only contains metal, but is continually broadcasting a signal they already know the frequency of. Much, much easier to find.

Factual error: Particles only annihilate upon joining their exact anti-particle counterparts, which is to say for example, electrons annihilate with positrons, protons with anti-protons, and so on. Several conservation laws would otherwise be broken. So when the magnetic field within the anti-matter bomb failed, all that could've occurred is the anti-protons would've met with surface electrons in the bomb's inner walls. On top of that, the surface electrons and the anti-protons all have equal negative charges, and thus would repel away from each other, never coming into intimate contact. The bomb would never have detonated.

Factual error: C.E.R.N. does not own any aircraft, let alone Thurderbirds style Mach 15 capable spaceships.